Cambridge IGCSE·Co-ordinated Sciences 0654·Biology
Diseases Immunity
Key knowledge — Diseases Immunity
Key facts & rules
- Pathogen types: bacteria (e.g. tuberculosis, Salmonella), viruses (e.g. influenza, HIV), fungi, protists (e.g. malaria).
- Transmission: direct contact, droplets, contaminated food/water, vectors (e.g. mosquitoes).
- Physical defences: skin, mucus, cilia (in trachea), stomach acid.
- Phagocytes: engulf and destroy pathogens (non-specific).
- Lymphocytes: produce specific antibodies that bind to antigens on pathogens.
- Memory cells: remain after infection → faster response if same pathogen returns (immunity).
- Vaccination: introduces antigens (dead/weakened/antigen only) → immune system produces antibodies + memory cells.
- Antibiotics: kill bacteria — NOT effective against viruses. Overuse causes antibiotic resistance.
IGCSE Biology — Diseases & immunity
112 Cambridge IGCSE 0654 biology past paper questions on diseases & immunity, organised by subtopic. Pick a subtopic to start practising.
About diseases & immunity on IGCSE 0654
Pathogens and transmissible disease, the body's defences, the immune response, and vaccination.